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Article

Covariance component models for multivariate binary traits in family data analysis.

Statistics in medicine - 30 Mar 2008

Yip Benjamin H, Björk Camilla, Lichtenstein Paul, Hultman Christina M, Pawitan Yudi

Abstract excerpt

For family studies, there is now an established analytical framework for binary-trait outcomes within the generalized linear mixed models (GLMMs). However, the corresponding analysis of multivariate binary-trait (MBT) outcomes is still limited. Certain diseases, such as schizophrenia and bipolar disorder, have similarities in epidemiological features, risk factor patterns and intermediate phenotypes. To have a...

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PMID: 17634971
DOI: 10.1002/sim.2996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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