Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Studies on Prn variation in the mouse model and comparison with epidemiological data.

PloS one - 25 Mar 2011

van Gent Marjolein, van Loo Inge H M, Heuvelman Kees J, de Neeling Albert J, Teunis Peter, Mooi Frits R

Abstract excerpt

The virulence factor pertactin (Prn) is a component of pertussis vaccines and one of the most polymorphic Bordetella pertussis antigens. After the introduction of vaccination shifts in predominant Prn types were observed and strains with the Prn vaccine type (Prn1) were replaced by strains carrying non-vaccine types (Prn2 and Prn3), suggesting vaccine-driven selection. The aim of this study was to elucidate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Outer Membrane Proteins
Share to Colony Count, Microbial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Gene Silencing

Share to Netherlands

Share to Respiratory System

Share to Virulence Factors, Bordetella

Share to Whooping Cough

Source

Open in PubMed Open full text

Identifiers

PMID: 21464955
DOI: 10.1371/journal.pone.0018014
PMCID: PMC3064647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Studies on Prn variation in the mouse model and comparison with epidemiological data.PMID 21464955Read ↗

Synergic effect of genotype changes in pertussis toxin and pertactin on adaptation to an acellular pertussis vaccine in the murine intranasal challenge model.Semantic proximity Read ↗

Prevalence and genetic characterization of pertactin-deficient Bordetella pertussis in Japan.Semantic proximity Read ↗

Evolution of French Bordetella pertussis and Bordetella parapertussis isolates: increase of Bordetellae not expressing pertactin.Semantic proximity Read ↗

Investigations into the emergence of pertactin-deficient Bordetella pertussis isolates in six European countries, 1996 to 2012.Semantic proximity Read ↗

Pertactin-Deficient Bordetella pertussis , Vaccine-Driven Evolution, and Reemergence of PertussisSemantic proximity Read ↗

Better colonisation of newly emerged Bordetella pertussis in the co-infection mouse model study.Semantic proximity Read ↗

Rapid increase in pertactin-deficient Bordetella pertussis isolates, Australia.Semantic proximity Read ↗

Polymorphism in Bordetella pertussis pertactin and pertussis toxin virulence factors in the United States, 1935-1999.Semantic proximity Read ↗

Genome-Wide Gene Expression Analysis of Bordetella pertussis Isolates Associated with a Resurgence in Pertussis: Elucidation of Factors Involved in the Increased Fitness of Epidemic StrainsSemantic proximity Read ↗

Role of the polymorphic region 1 of the Bordetella pertussis protein pertactin in immunitySemantic proximity Read ↗

Variation in the Bordetella pertussis virulence factors pertussis toxin and pertactin in vaccine strains and clinical isolates in Finland.Semantic proximity Read ↗

Small mutations in Bordetella pertussis are associated with selective sweeps.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.