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Article

Prevalence and genetic characterization of pertactin-deficient Bordetella pertussis in Japan.

PloS one - 1 Jan 2012

Otsuka Nao, Han Hyun-Ja, Toyoizumi-Ajisaka Hiromi, Nakamura Yukitsugu, Arakawa Yoshichika, Shibayama Keigo, Kamachi Kazunari

Abstract excerpt

The adhesin pertactin (Prn) is one of the major virulence factors of Bordetella pertussis, the etiological agent of whooping cough. However, a significant prevalence of Prn-deficient (Prn(-)) B. pertussis was observed in Japan. The Prn(-) isolate was first discovered in 1997, and 33 (27%) Prn(-) isolates were identified among 121 B. pertussis isolates collected from 1990 to 2009. Sequence analysis revealed that...

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Share to Bacterial Outer Membrane Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22348138
DOI: 10.1371/journal.pone.0031985
PMCID: PMC3279416

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