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Pertactin-Deficient Bordetella pertussis , Vaccine-Driven Evolution, and Reemergence of Pertussis

19 May 2021

Abstract excerpt

Recent reemergence of pertussis (whooping cough) in highly vaccinated populations and rapid expansion of Bordetella pertussis strains lacking pertactin (PRN), a common acellular vaccine antigen, have raised the specter of vaccine-driven evolution and potential return of what was once the major killer of children. The discovery that most circulating B. pertussis strains in the United States have acquired new and...

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PMID: 34014152
DOI: 10.3201/eid2706.203850

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