Article
Rapid increase in pertactin-deficient Bordetella pertussis isolates, Australia.
Emerging infectious diseases - 1 Apr 2014
Lam Connie, Octavia Sophie, Ricafort Lawrence, Sintchenko Vitali, Gilbert Gwendolyn L, Wood Nicholas, McIntyre Peter, Marshall Helen, Guiso Nicole, Keil Anthony D, Lawrence Andrew, Robson Jenny, Hogg Geoff, Lan Ruiting
Abstract excerpt
Acellular vaccines against Bordetella pertussis were introduced in Australia in 1997. By 2000, these vaccines had replaced whole-cell vaccines. During 2008-2012, a large outbreak of pertussis occurred. During this period, 30% (96/320) of B. pertussis isolates did not express the vaccine antigen pertactin (Prn). Multiple mechanisms of Prn inactivation were documented, including IS481 and IS1002 disruptions, a...
Topics
- Alleles
- Antigens, Bacterial
- Australia
- Bacterial Outer Membrane Proteins
- Bordetella pertussis
- Pertussis Toxin
- Pertussis Vaccine
- Virulence Factors, Bordetella
- Whooping Cough