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Article

Rapid increase in pertactin-deficient Bordetella pertussis isolates, Australia.

Emerging infectious diseases - 1 Apr 2014

Lam Connie, Octavia Sophie, Ricafort Lawrence, Sintchenko Vitali, Gilbert Gwendolyn L, Wood Nicholas, McIntyre Peter, Marshall Helen, Guiso Nicole, Keil Anthony D, Lawrence Andrew, Robson Jenny, Hogg Geoff, Lan Ruiting

Abstract excerpt

Acellular vaccines against Bordetella pertussis were introduced in Australia in 1997. By 2000, these vaccines had replaced whole-cell vaccines. During 2008-2012, a large outbreak of pertussis occurred. During this period, 30% (96/320) of B. pertussis isolates did not express the vaccine antigen pertactin (Prn). Multiple mechanisms of Prn inactivation were documented, including IS481 and IS1002 disruptions, a...

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Identifiers

PMID: 24655754
DOI: 10.3201/eid2004.131478
PMCID: PMC3966384

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Source receipt: pubmed, retrieved 7 Sept 2026.

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