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Article

Synergic effect of genotype changes in pertussis toxin and pertactin on adaptation to an acellular pertussis vaccine in the murine intranasal challenge model.

Clinical and vaccine immunology : CVI - 1 May 2010

Komatsu Eiji, Yamaguchi Fuminori, Abe Akio, Weiss Alison A, Watanabe Mineo

Abstract excerpt

The Bordetella pertussis pertussis toxin and pertactin (Prn) are protective antigens and are contained in acellular pertussis vaccines. Polymorphisms in the A subunit of pertussis toxin (PtxA) and pertactin have been proposed to mediate vaccine resistance and contribute to pertussis reemergence. To test this hypothesis, previous studies compared clinical isolates expressing different alleles for the proteins....

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Source

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Identifiers

PMID: 20357056
DOI: 10.1128/CVI.00449-09
PMCID: PMC2863393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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