Article
Helicobacter pylori urease activity is influenced by ferric uptake regulator.
Yonsei medical journal - 1 Jan 2010
Lee Jong Seung, Choe Yon Ho, Lee Ji Hyuk, Lee Hye Jin, Lee Jee Hyun, Choi Young Ok
Abstract excerpt
PURPOSE: The role of the Ferric Uptake Regulator (FUR) in the acid resistance of Helicobacter pylori (H. pylori) has been thought to be independent of urease. However, we demonstrated in this study that Fur influences urease activity. MATERIALS AND METHODS: A fur knockout mutant of H. pylori was constructed by replacing the Fur gene with a kanamycin resistant marker gene. The wild-type H. pylori and fur mutant...
Topics
- Bacterial Proteins
- Helicobacter pylori
- Hydrogen-Ion Concentration
- Microscopy, Confocal
- Models, Biological
- Mutation
- Repressor Proteins
- Urease
