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Article

Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype.

American journal of physiology. Lung cellular and molecular physiology - 1 Jun 2011

Risse Paul-André, Jo Taisuke, Suarez Fernando, Hirota Nobuaki, Tolloczko Barbara, Ferraro Pasquale, Grutter Peter, Martin James G

Abstract excerpt

IL-13 is an important mediator of allergen-induced airway hyperresponsiveness. This Th2 cytokine, produced by activated T cells, mast cells, and basophils, has been described to mediate a part of its effects independently of inflammation through a direct modulation of the airway smooth muscle (ASM). Previous studies demonstrated that IL-13 induces hyperresponsiveness in vivo and enhances calcium signaling in...

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PMID: 21460123
DOI: 10.1152/ajplung.00247.2010

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