Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effects of aging and genotype on NMDA receptor expression in growth hormone receptor knockout (GHRKO) mice.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jun 2011

Magnusson Kathy Ruth, Das Siba Ranjan, Kronemann Daniel, Bartke Andrzej, Patrylo Peter R

Abstract excerpt

Caloric restriction enhances N-methyl-D-aspartate (NMDA) receptor binding and upregulates messenger RNA expression of the GluN1 subunit during aging. Old growth hormone receptor knockout mice resemble old calorically restricted rodents in enhanced life span and brain function, as compared with aged controls. This study examined whether aged growth hormone receptor knockout mice also show enhanced expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Glutamic Acid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred Strains

Share to Mice, Knockout

Share to Receptors, N-Methyl-D-Aspartate

Share to Receptors, Somatotropin

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 21459761
DOI: 10.1093/gerona/glr024
PMCID: PMC3110907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

The effects of aging and genotype on NMDA receptor expression in growth hormone receptor knockout (GHRKO) mice.PMID 21459761Read ↗

Alterations in regional brain metabolism in genetic and pharmacological models of reduced NMDA receptor function.Semantic proximity Read ↗

Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging.Semantic proximity Read ↗

A neuregulin 1 transmembrane domain mutation causes imbalanced glutamatergic and dopaminergic receptor expression in mice.Semantic proximity Read ↗

Is altered expression of hepatic insulin-related genes in growth hormone receptor knockout mice due to GH resistance or a difference in biological life spans?Semantic proximity Read ↗

Premature aging in vitamin D receptor mutant mice.Semantic proximity Read ↗

Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain.Semantic proximity Read ↗

Glutamate-dependent regulation of food intake is altered with age through changes in NMDA receptor phenotypes on vagal afferent neurons.Semantic proximity Read ↗

Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice.Semantic proximity Read ↗

GABAA receptor messenger RNA expression in the deep cerebellar nuclei of Purkinje cell degeneration mutants is maintained following the loss of innervating Purkinje neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.