GABAA receptor messenger RNA expression in the deep cerebellar nuclei of Purkinje cell degeneration mutants is maintained following the loss of innervating Purkinje neurons.

Abstract excerpt

Recent studies have suggested that innervation modulates GABAA receptor gene expression in the rodent cerebellum. To examine this question, the expression and levels of GABAA receptor subunit messenger RNAs in the deep cerebellar nuclei of Purkinje cell degeneration mice and littermate controls were examined by quantitative in situ hybridization histochemistry. In the Purkinje cell degeneration mutant, the...

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