Article
Involvement of the serrated neoplasia pathway in inflammatory bowel disease-related colorectal oncogenesis.
Oncology reports - 1 Nov 2007
Bossard Céline, Denis Marc G, Bézieau Stéphane, Bach-Ngohou Kalyane, Bourreille Arnaud, Laboisse Christian L, Mosnier Jean-François
Abstract excerpt
The purpose of this study is to identify colorectal serrated lesions in the inflammatory mucosa of inflammatory bowel disease (IBD), to characterize their molecular status based on BRAF and KRAS mutations, mismatch-repair (MMR) deficiency and microsatellite instability (MSI), and to verify that these molecular alterations are specific to the 'serrated neoplasia pathway' in IBD. Neoplastic lesions from 36 patients...
Topics
- Adenocarcinoma
- Adenoma
- Colonic Polyps
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- DNA Mismatch Repair
- DNA, Neoplasm
- Genetic Markers
- Humans
- Inflammatory Bowel Diseases
- Microsatellite Instability
- Mutation