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Article

Genetic variation in genes encoding for polymerase ζ subunits associates with breast cancer risk, tumour characteristics and survival.

Breast cancer research and treatment - 1 Aug 2011

Varadi Verena, Bevier Melanie, Grzybowska Ewa, Johansson Robert, Enquist Kerstin, Henriksson Roger, Butkiewicz Dorota, Pamula-Pilat Jolanta, Tecza Karolina, Hemminki Kari, Lenner Per, Försti Asta

Abstract excerpt

Chromosomal instability is a known hallmark of many cancers. DNA polymerases represent a group of enzymes that are involved in the mechanism of chromosomal instability as they have a central function in DNA metabolism. We hypothesized that genetic variation in the polymerase genes may affect gene expression or protein configuration and by that cancer risk and clinical outcome. We selected four genes encoding for...

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Identifiers

PMID: 21455670
DOI: 10.1007/s10549-011-1460-z

Genes

POLB
POLD1
POLQ
REV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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