Article
Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm.
The Journal of biological chemistry - 13 May 2011
Veitinger Thomas, Riffell Jeffrey R, Veitinger Sophie, Nascimento Jaclyn M, Triller Annika, Chandsawangbhuwana Charlie, Schwane Katlen, Geerts Andreas, Wunder Frank, Berns Michael W, Neuhaus Eva M, Zimmer Richard K, Spehr Marc, Hatt Hanns
Abstract excerpt
In the female reproductive tract, mammalian sperm undergo a regulated sequence of prefusion changes that "prime" sperm for fertilization. Among the least understood of these complex processes are the molecular mechanisms that underlie sperm guidance by environmental chemical cues. A "hard-wired" Ca(2+) signaling strategy that orchestrates specific motility patterns according to given functional requirements is an...
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