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Article

Molecular Mechanism for Human Sperm Chemotaxis Mediated by Progesterone

8 Dec 2009

Abstract excerpt

Sperm chemotaxis is a chemical guiding mechanism that may orient spermatozoa to the egg surface. A picomolar concentration gradient of Progesterone (P), the main steroidal component secreted by the cumulus cells that surround the egg, attracts human spermatozoa. In order to elucidate the molecular mechanism of sperm chemotaxis mediated by P, we combine the application of different strategies: pharmacological...

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PMID: 19997608
DOI: 10.1371/journal.pone.0008211

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