Article
A mixture of bacterial mechanical lysates is more efficient than single strain lysate and of bacterial-derived soluble products for the induction of an activating phenotype in human dendritic cells.
Immunology letters - 1 Jul 2011
Morandi Barbara, Agazzi Alessia, D'Agostino Antonella, Antonini Francesca, Costa Gregorio, Sabatini Federica, Ferlazzo Guido, Melioli Giovanni
Abstract excerpt
Dendritic cells (DCs), following an optimal maturation, are able to drive an efficient immune-response. For this, both co-stimulatory molecules (CD80 and CD86), activation molecules (CD83) and peptide presenting molecules (HLA) are over-expressed. The in vitro treatment of immature DC with fragments of bacterial strains, obtained by using a mechanical lysis as well as with bacterial-derived molecules (such as...
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