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Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage

16 Feb 2016

Abstract excerpt

OBJECTIVE: To analyze the methylome of normal and osteoarthritic (OA) knee articular cartilage and to determine the role of DNA methylation in the regulation of gene expression in vitro. METHODS: DNA was isolated from human normal (n = 11) and OA (n = 12) knee articular cartilage and analyzed using the Infinium HumanMethylation450 BeadChip array. To integrate methylation and transcription, RNA sequencing was...

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PMID: 26881698
DOI: 10.1002/art.39643

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