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Article

Replication and pathogenicity of attenuated human metapneumovirus F mutants in severe combined immunodeficiency mice.

Vaccine - 5 Jan 2012

Yu Chun-mei, Li Rong-pei, Chen Xin, Liu Ping, Zhao Xiao-dong

Abstract excerpt

This study was to evaluate the replication and pathogenicity of attenuated human metapneumovirus (HMPV) mutants in severe combined immunodeficiency (SCID) mice. SCID mice were intranasally infected with either wild type GFP-rHMPV (WT), or mutant viruses (M1, M2 and M4) with the N-linked glycosylation(s) of the F protein removed. The organs were collected for viral isolation, titration, pulmonary histopathology...

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Identifiers

PMID: 22085552
DOI: 10.1016/j.vaccine.2011.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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