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A novel multiplex RNAi therapy simultaneously targets <i>Hif1a</i> and <i>Hif2a</i> to defy retinal degeneration in two models of AMD

2024-11-30

Abstract excerpt

Age-related tissue changes lead to reduced oxygen delivery to photoreceptors and the retinal pigment epithelium (RPE), and contribute to the pathology of age-related macular degeneration (AMD). The implication of hypoxia-inducible factors (HIFs) in this process makes them good candidates as therapeutic targets for AMD. We developed a multiplex dual-acting therapy utilizing the shRNAmir system, delivered by a singl...

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Literature Corpus work
6f9edff3-df7d-5768-8213-d55e3c8b2490
DOI
10.1101/2024.11.29.626080
Open publication

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A novel multiplex RNAi therapy simultaneously targets <i>Hif1a</i> and <i>Hif2a</i> to defy retinal degeneration in two models of AMDDOI 10.1101/2024.11.29.626080
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