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Article

Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1.

Cell research - 1 Jul 2011

Bai Lin, Deng Xiaoli, Li Juanjuan, Wang Miao, Li Qian, An Wei, A Deli, Cong Yu-Sheng

Abstract excerpt

Polymerase I and transcript release factor (PTRF, also known as Cavin-1) is an essential component in the biogenesis and function of caveolae. Here, we show that PTRF expression is increased in senescent human fibroblasts. Importantly, overexpression of PTRF induced features characteristic of cellular senescence, whereas reduced PTRF expression extended the cellular replicative lifespan. Interestingly, we found...

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Identifiers

PMID: 21445100
DOI: 10.1038/cr.2011.56
PMCID: PMC3193497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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