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Article

Nuclear Accumulation of Globular Actin as a Cellular Senescence Marker

15 Jan 2004

Abstract excerpt

We evaluated the nuclear actin accumulation as a new marker of cellular senescence, using human diploid fibroblast (HDF), chondrocyte primary cultures, Mv1Lu epithelial cells, and Huh7 cancer cells. Nuclear accumulation of globular actin (G-actin) and dephosphorylated cofilin was highly significant in the senescent HDF cells, accompanied with inhibition of LIM kinase (LIMK) -1 activity. When nuclear export of the...

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PMID: 14744771
DOI: 10.1158/0008-5472.can-03-1856

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