Control of fibroblast senescence and activation of programmed cell death.

Abstract excerpt

We have characterized a nuclear phosphoprotein of 57 kda, statin, found only in nonproliferating cells of both quiescent and senescent natures. Emerging results suggest that statin may function as a sequester to block the early G1 phase phosphorylation for the RB protein. A second protein, terminin, undergoes senescence-specific posttranslational modification from 90 to 60 kda, and further death-specific...

Topics

• Animals
• Cell Death
• Cell Division
• Cellular Senescence
• Fibroblasts
• Gene Expression Regulation
• Humans
• Phenotype