Article
Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46.
Biochemistry - 8 Nov 2005
Zilka Alon, Landau Guy, Hershkovitz Oren, Bloushtain Noga, Bar-Ilan Ahuva, Benchetrit Fabrice, Fima Eyal, van Kuppevelt Toin H, Gallagher John T, Elgavish Sharona, Porgador Angel
Abstract excerpt
NKp46 is a member of a group of receptors collectively termed natural cytotoxicity receptors (NCRs) that are expressed by natural killer (NK) cells. NCRs are capable of mediating direct killing of tumor and virus-infected cells by NK cells. We have recently shown that NKp46 recognizes the heparan sulfate moieties of membranal heparan sulfate proteoglycans (HSPGs), thus enabling lysis of tumor cells by NK cells....
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