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Article

Altered protamine expression and diminished spermatogenesis: what is the link?

5 Jan 2007

Abstract excerpt

During the elongating spermatid stage of spermiogenesis, human sperm chromatin undergoes a complex transition in which histones are extensively replaced by protamines in a carefully regulated transition including histone modifications and intermediate and temporary replacement of the histones by sperm-specific transition proteins. The replacement of most histones by protamines 1 and 2 facilitates a high order of...

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Identifiers

PMID: 17208950
DOI: 10.1093/humupd/dml057

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