Article
Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice.
Journal of neural transmission (Vienna, Austria : 1996) - 1 May 2011
Attems Johannes, Ittner Arne, Jellinger Kurt, Nitsch Roger M, Maj Magdalena, Wagner Ludwig, Götz Jürgen, Heikenwalder Mathias
Abstract excerpt
Neuropathological features in Alzheimer's Disease (AD) include the presence of hyperphosphorylated forms of the microtubule-associated tau protein (tau) in hippocampal neurones. Numerous studies indicate a neuroprotective effect of calcium-binding proteins (Ca2+ binding proteins) in neurodegenerative diseases (e.g., AD). Secretagogin is a newly described Ca2+ binding protein that is produced by pyramidal neurones...
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