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Article

Consequences of hyperphosphorylated tau on the morphology and excitability of hippocampal neurons in aged tau transgenic mice.

Neurobiology of aging - 1 Sept 2020

Müller-Thomsen Lennart, Borgmann Diba, Morcinek Kerstin, Schröder Sophia, Dengler Brigitte, Moser Natasha, Neumaier Felix, Schneider Toni, Schröder Hannsjörg, Huggenberger Stefan

Abstract excerpt

The intracellular accumulation of hyperphosphorylated tau characterizes many neurodegenerative diseases such as Alzheimer's disease and frontotemporal dementia. A critical role for tau is supported by studies in transgenic mouse models expressing the P301L mutation with accumulation of hyperphosphorylated human tau in hippocampal pyramidal neurons of aged mice. Especially, the somatodendritic mislocalization of...

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PMID: 32278495
DOI: 10.1016/j.neurobiolaging.2020.03.007

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