Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fyn Kinase Modulates Synaptotoxicity, But Not Aberrant Sprouting, in Human Amyloid Precursor Protein Transgenic Mice

12 May 2004

Abstract excerpt

Alzheimer's disease (AD), the most common neurodegenerative disorder, results in progressive degeneration of synapses and aberrant sprouting of axon terminals. The mechanisms underlying these seemingly opposing cellular phenomena are unclear. We hypothesized that Fyn kinase may play a role in one or both of these processes because it is increased in AD brains and because it is involved in synaptic plasticity and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroscience and Neuropharmacology Research
Share to S100 Proteins and Annexins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15140940
DOI: 10.1523/jneurosci.0277-04.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fyn Kinase Modulates Synaptotoxicity, But Not Aberrant Sprouting, in Human Amyloid Precursor Protein Transgenic MicePMID 15140940Read ↗

Synaptogenic effect of APP-Swedish mutation in familial Alzheimer's disease.Semantic proximity Read ↗

High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque FormationSemantic proximity Read ↗

p75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model.Semantic proximity Read ↗

Cholinergic Basal Forebrain Lesion Decreases Neurotrophin Signaling without Affecting Tau Hyperphosphorylation in Genetically Susceptible Mice.Semantic proximity Read ↗

Synaptic vulnerability in neurodegenerative disease.Semantic proximity Read ↗

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.Semantic proximity Read ↗

Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spinesSemantic proximity Read ↗

Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.Semantic proximity Read ↗

Synaptopathy: presynaptic convergence in frontotemporal dementia and amyotrophic lateral sclerosis.Semantic proximity Read ↗

FAD-mutation of APP is associated with a loss of its synaptotrophic activity.Semantic proximity Read ↗

Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and LossSemantic proximity Read ↗

7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.