Article
Allelic imbalance of tissue-type plasminogen activator (t-PA) gene expression in human brain tissue.
Thrombosis and haemostasis - 1 Jun 2011
Tjarnlund-Wolf A, Hultman K, Curtis M A, Faull R L M, Medcalf R L, Jern C
Abstract excerpt
We have identified a single-nucleotide polymorphism (SNP) in the t-PA enhancer (-7351C>T), which is associated with endothelial t-PA release in vivo. In vitro studies demonstrated that this SNP is functional at the level of transcription. In the brain, t-PA has been implicated in both physiologic and pathophysiologic processes. The aim of the present study was to examine the effect of the t-PA -7351C>T SNP on...
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