Article
A novel polymorphic AP-1 binding element of the GFAP promoter is associated with different allelic transcriptional activities.
Annals of human genetics - 1 Nov 2010
Bachetti Tiziana, Di Zanni Eleonora, Lantieri Francesca, Caroli Francesco, Regis Stefano, Filocamo Mirella, Rainero Innocenzo, Gallone Salvatore, Cilia Roberto, Romano Silvia, Savoiardo Mario, Pareyson Davide, Biancheri Roberta, Ravazzolo Roberto, Ceccherini Isabella
Abstract excerpt
The Glial Fibrillary Acidic Protein (GFAP) gene encodes a cytoskeletal protein belonging to the intermediate filament family whose expression is considered as a marker of astrocytes differentiation. GFAP expression, shown to be upregulated as a consequence of brain gliosis, depends on hormones, g...
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