Article
Tissue-type plasminogen activator -7,351C/T enhancer polymorphism is associated with a first myocardial infarction.
Thrombosis and haemostasis - 1 Jan 2002
Ladenvall Per, Johansson Lars, Jansson Jan-Håkan, Jern Sverker, Nilsson Torbjörn K, Tjärnlund Anna, Jern Christina, Boman Kurt
Abstract excerpt
We recently identified a polymorphic Sp1 binding site in an enhancer at the tissue-type plasminogen activator (tPA) locus (tPA -7,351C/T), which was associated with vascular tPA release. Subjects homozygous for the -7,351C allele had twice the tPA release rate compared to subjects carrying the -7,351T allele. In this study we tested the hypothesis that the tPA -7,351C/T polymorphism is associated with myocardial...
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