Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation at the human tissue-type plasminogen activator (tPA) locus: haplotypes and analysis of association to plasma levels of tPA.

European journal of human genetics : EJHG - 1 Aug 2003

Ladenvall P, Nilsson S, Jood K, Rosengren A, Blomstrand C, Jern C

Abstract excerpt

Tissue-type plasminogen activator (tPA) plays a key role in thrombus dissolution and plasma levels of tPA have been associated with cardiovascular disease. We have previously resequenced regulatory and coding regions of the human tPA gene (PLAT) and identified eight single-nucleotide polymorphisms (SNPs). In a small experimental study, four common variants were associated with invasively determined vascular tPA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Haplotypes

Share to Linkage Disequilibrium

Share to Plasminogen Activator Inhibitor 1

Share to Polymorphism, Genetic

Share to Tissue Plasminogen Activator

Source

Identifiers

PMID: 12891381
DOI: 10.1038/sj.ejhg.5201011

Genes

PLAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation at the human tissue-type plasminogen activator (tPA) locus: haplotypes and analysis of association to plasma levels of tPA.PMID 12891381Read ↗

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.Semantic proximity Read ↗

Haplotypes of the plasminogen activator gene associated with ischemic stroke.Semantic proximity Read ↗

Identification of eight novel single-nucleotide polymorphisms at human tissue-type plasminogen activator (t-PA) locus: association with vascular t-PA release in vivo.Semantic proximity Read ↗

Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels.Semantic proximity Read ↗

Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk.Semantic proximity Read ↗

Tissue-type plasminogen activator -7,351C/T enhancer polymorphism is associated with a first myocardial infarction.Semantic proximity Read ↗

Analysis of sequence variations in the promoter region of the human tissue factor pathway inhibitor 2 gene in apoplectic patients and blood donors.Semantic proximity Read ↗

Allelic dimorphism in the human tissue-type plasminogen activator (TPA) gene as a result of an Alu insertion/deletion event.Semantic proximity Read ↗

Identification of polymorphisms in the promoter and the 3' region of the TAFI gene: evidence that plasma TAFI antigen levels are strongly genetically controlled.Semantic proximity Read ↗

Association of genetic variants of fibrinolytic system with stroke and stroke subtypes.Semantic proximity Read ↗

Linkage disequilibrium and haplotype analysis among eight novel single-nucleotide polymorphisms in the human tissue-type plasminogen activator (t-PA) gene.Semantic proximity Read ↗

Dinucleotide repeat polymorphism at the human tissue plasminogen activator gene (PLAT).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.