Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development.

PLoS genetics - 1 Mar 2011

Koester-Eiserfunke Nora, Fischle Wolfgang

Abstract excerpt

MBT domain proteins are involved in developmental processes and tumorigenesis. In vitro binding and mutagenesis studies have shown that individual MBT domains within clustered MBT repeat regions bind mono- and dimethylated histone lysine residues with little to no sequence specificity but discriminate against the tri- and unmethylated states. However, the exact function of promiscuous histone methyl-lysine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Histones

Share to Protein Binding

Share to Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 21437264
DOI: 10.1371/journal.pgen.1002017
PMCID: PMC3060068

Genes

MET
SETDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development.PMID 21437264Read ↗

LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes.Semantic proximity Read ↗

Argonaute NRDE-3 and MBT domain protein LIN-61 redundantly recruit an H3K9me3 HMT to prevent embryonic lethality and transposon expression.Semantic proximity Read ↗

SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity.Semantic proximity Read ↗

Two<i>C. elegans</i>histone methyltransferases repress<i>lin-3</i>EGF transcription to inhibit vulval developmentSemantic proximity Read ↗

gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans.Semantic proximity Read ↗

LIN-15B promotes enrichment of H3K9me2 on the promoters of a subset of germline genes that are repressed in somatic cells in C. elegansSemantic proximity Read ↗

WDR-5 exhibits H3K4 methylation-independent activity during embryonic development in C. elegansSemantic proximity Read ↗

Maternal H3K36 and H3K27 HMTs protect germline immortality via regulation of the transcription factor LIN-15BSemantic proximity Read ↗

Enrichment of H3K9me2 on Unsynapsed Chromatin in Caenorhabditis elegans Does Not Target de Novo Sites.Semantic proximity Read ↗

dSet1 is the main H3K4 di- and tri-methyltransferase throughout Drosophila development.Semantic proximity Read ↗

A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.Semantic proximity Read ↗

<i>C. elegans</i> synMuv B proteins regulate spatial and temporal chromatin compaction during developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.