Article

Hyperinsulinemia promotes aberrant histone acetylation in triple negative breast cancer

2018-12-21

Abstract excerpt

Excess levels of insulin relative to glucose in the blood, or hyperinsulinemia, is considered to be a poor prognostic indicator for patients with triple negative breast cancer (TNBC). While this association has been recognized for some time, the mechanistic role of hyperinsulinemia in promoting TNBC remains unclear. We show that insulin treatment leads to genome-wide increase in histone acetylation, in particular...

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Literature Corpus work: 62ec00ea-9061-5616-acf4-e1393c0589f5
DOI: 10.1101/503201

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