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Article

Dichotomous effects of latent CMV infection on the phenotype and functional properties of CD8+ T-cells and NK-cells.

Cellular immunology - 1 Feb 2016

Bigley Austin B, Spielmann Guillaume, Agha Nadia, O'Connor Daniel P, Simpson Richard J

Abstract excerpt

CMV markedly alters the phenotype and function of NK-cells and T-cells and has been linked to immunosenescence. We show here that subjects with effective CMV control (evidenced by low CMV IgG titers) have functional responses to CMV that are driven by either NKG2C+ NK-cells or CMV-specific T-cells (15 of 24 subjects), but not both. These data indicate that people with effective CMV control are either NK-cell or...

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Identifiers

PMID: 26651951
DOI: 10.1016/j.cellimm.2015.11.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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