Article
Multiple suppressive effects of transforming growth factor beta 1 on the immune response in chickens.
Cellular immunology - 1 Sept 1990
Quere P, Thorbecke G J
Abstract excerpt
The immunosuppressive effect of human recombinant TGF-beta 1 on chicken immune responses in vitro was evaluated. TGF-beta 1 at 1-10 ng/ml reduced T cell proliferation in response to concanavalin A by 50-80% and B cell proliferation in response to LPS by greater than 90%. In contrast, when added to immune spleen cells, it reduced the secondary PFC response to sheep erythrocytes by less than 50%, particularly when...
Topics
- Animals
- Antibody Formation
- B-Lymphocytes
- Cell Division
- Chickens
- Hemolytic Plaque Technique
- Immune Tolerance
- In Vitro Techniques
- Phenotype
- Spleen
- T-Lymphocytes
- T-Lymphocytes, Regulatory