Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

Article

Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1991

Tada T, Ohzeki S, Utsumi K, Takiuchi H, Muramatsu M, Li X F, Shimizu J, Fujiwara H, Hamaoka T

Abstract excerpt

The present study investigates the nature of humoral component(s) generated in tumor-bearing hosts to induce immune dysfunction of T cells. Cell-free ascitic fluid and culture supernatant (SN) were obtained from the ascites and cultures allowing MH134 hepatoma cells to grow. These ascites and SN samples were tested for their abilities to influence the generation of CTL responses to TNP and alloantigens. The...

Topics

Animals
CD4-Positive T-Lymphocytes
Female
Immune Tolerance
Interleukin-2
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Neoplasms, Experimental
Phenotype

Recombinant Proteins

T-Lymphocytes, Cytotoxic

T-Lymphocytes, Regulatory

Transforming Growth Factor beta

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