Clinical and immunological effects of human recombinant interleukin-2 given by repetitive weekly infusion to normal dogs.

doi:10.1007/BF01525313

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Clinical and immunological effects of human recombinant interleukin-2 given by repetitive weekly infusion to normal dogs.

Cancer immunology, immunotherapy : CII - 1 Aug 1994

Helfand S C, Soergel S A, MacWilliams P S, Hank J A, Sondel P M

Abstract excerpt

Four normal adult dogs received two consecutive weekly cycles of human recombinant interleukin-2 (IL-2) by continuous infusion for 4 days/week. The dose of IL-2 given to each dog was 3 x 10(6) units m-2 day-1. Toxicities consisted of mild vomiting, diarrhea, and lethargy to varying degrees in all...

Topics

Adenocarcinoma
Animals
Cytotoxicity, Immunologic
Disease Models, Animal
Dogs
Drug Administration Schedule
Immunotherapy
Infusions, Intravenous
Interleukin-2
Lymphocyte Activation
Lymphocytes
Phenotype
Recombinant Proteins
Thyroid Neoplasms
Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 8044833
DOI: 10.1007/BF01525313
PMCID: PMC11038981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8044833-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics