Article
Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy.
Biochemical and biophysical research communications - 31 Jul 1990
Ozawa T, Tanaka M, Sugiyama S, Hattori K, Ito T, Ohno K, Takahashi A, Sato W, Takada G, Mayumi B
Abstract excerpt
Genetic impairment was revealed in idiopathic cardiomyopathy and the responsible DNA locus was estimated. Mitochondrial DNA were amplified from autopsied cardiac specimens from three patients who died from hypertrophic or dilated cardiomyopathy by using polymerase chain reaction (PCR). By using two novel methods for PCR gene amplification, the pleioplasmic existence of multiple populations of differently deleted...
Topics
- Adenosine Triphosphatases
- Adult
- Base Sequence
- Blotting, Southern
- Cardiomyopathy, Dilated
- Cardiomyopathy, Hypertrophic
- Chromosome Deletion
- DNA, Mitochondrial
- Female
- Humans