Article
[ Mutation of mtDNA and genetic background of hypertrophic cardiomyopathy].
Wiadomosci lekarskie (Warsaw, Poland : 1960) - 1 Jan 2002
Latocha Małgorzata T, Kościelny Marek, Mazurek Urszula M
Abstract excerpt
The operation of the structural and functional units of the myocardial contractile apparatus relies on mutual myofilament movement, totally ATP dependent. As a consequence, cardiac action is integrally connected with the production of high energy ATP molecules, which are mainly synthesised in cellular mitochondrial structures. Mitochondrial dysfunction can lead to a reduced level of ATP, which is necessary to...
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