Article
Cardiac mitochondrial dysfunction and DNA depletion in children with hypertrophic cardiomyopathy.
Journal of inherited metabolic disease - 1 Sept 1997
Marin-Garcia J, Ananthakrishnan R, Goldenthal M J, Filiano J J, Perez-Atayde A
Abstract excerpt
Abnormalities in specific mitochondrial respiratory enzymes and DNA (mtDNA) have been reported in cardiomyopathy. In this study, we report 4 cases of severe hypertrophic cardiomyopathy (HCM) in which specific cardiac mitochondrial enzyme activity defects were found, including complex I (n = 2), complex III (n = 2), complex IV (n = 2) and complex V (n = 1). Other abnormalities were also noted including a marked...
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