Article
Mitochondrial DNA variations associated with hypertrophic cardiomyopathy.
Mitochondrion - 1 May 2014
Govindaraj Periyasamy, Khan Nahid Akhtar, Rani Bindu, Rani Deepa Selvi, Selvaraj Priyadharshini, Jyothi Vuskamalla, Bahl Ajay, Narasimhan Calambur, Rakshak Dharma, Premkumar Kumpati, Khullar Madhu, Thangaraj Kumarasamy
Abstract excerpt
Hypertrophic cardiomyopathy (HCM) is a primary disorder, characterized by unexplained hypertrophy of the left ventricle that frequently involved in the inter-ventricular septum. Mitochondrial DNA (mtDNA) mutations and haplogroups have been found to be associated with several diseases. Therefore, in the present study, we have sequenced the complete mtDNA of 114 clinically well-characterized HCM patients to look...
Topics
- Adolescent
- Adult
- Aged
- Cardiomyopathy, Hypertrophic
- Child
- DNA, Mitochondrial
- Female
- Genetic Association Studies
- Haplotypes
- Humans
- India
- Male
- Metabolic Networks and Pathways