Article
Mitochondrial DNA mutations and disturbances of energy metabolism in myocardium.
Japanese circulation journal - 1 Nov 1991
Ozawa T, Sugiyama S, Tanaka M, Hattori K
Abstract excerpt
Since mitochondria occupy a pivotal position in energy metabolism, mitochondrial dysfunction is directly linked with disturbances in cellular function. Mitochondria possess their own DNA, which codes 13 subunits of the mitochondrial energy transducing system; the other subunits are coded by nuclear DNA. Recent advances in gene technology, especially the polymerase chain reaction (PCR), permit us to analyze...
Topics
- Adenosine Triphosphate
- Adult
- Base Sequence
- Cardiomyopathies
- Chromosome Deletion
- DNA Mutational Analysis
- DNA, Mitochondrial
- Energy Metabolism
- Female
- Humans
- Male
- Middle Aged
