Patients with idiopathic cardiomyopathy belong to the same mitochondrial DNA gene family of Parkinson's disease and mitochondrial encephalomyopathy.

doi:10.1016/0006-291x(91)92014-b

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Article

Patients with idiopathic cardiomyopathy belong to the same mitochondrial DNA gene family of Parkinson's disease and mitochondrial encephalomyopathy.

Biochemical and biophysical research communications - 31 May 1991

Ozawa T, Tanaka M, Sugiyama S, Ino H, Ohno K, Hattori K, Ohbayashi T, Ito T, Deguchi H, Kawamura K

Abstract excerpt

Comparison of total mitochondrial DNA sequences of patients with idiopathic (deleted or hypertrophic) cardiomyopathy with those of patients with Parkinson's disease and mitochondrial encephalomyopathies revealed distinct clustering of point mutations among patients. Furthermore, an inverse relation was found between the total number of base-substitution and life span of the patients. Among point mutations found...

Topics

Adult
Base Sequence
Cardiomyopathies
Cardiomyopathy, Hypertrophic
Central Nervous System Diseases
DNA, Mitochondrial
Electrocardiography
Female
Humans
Male

Mitochondria, Muscle

Molecular Sequence Data

Multigene Family

Mutation

Myocardium

Nucleic Acid Conformation

Parkinson Disease

Pedigree

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