Point mutations in mitochondrial DNA of patients with dilated cardiomyopathy.

doi:10.1006/jmcc.1997.0501

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Article

Point mutations in mitochondrial DNA of patients with dilated cardiomyopathy.

Journal of molecular and cellular cardiology - 1 Oct 1997

Li Y Y, Maisch B, Rose M L, Hengstenberg C

Abstract excerpt

Mitochondrial (mt) DNA mutations are hypothesized to be involved in the pathogenesis of dilated cardiomyopathy, because the mtDNA encodes 13 polypeptides that are essential for oxidative phosphorylation, upon which the heart relies for energy. To test this hypothesis, we amplified the mitochondri...

Topics

Adult
Age Factors
Cardiomyopathy, Dilated
DNA, Mitochondrial
Genetic Variation
Humans
Infant
Middle Aged
Nucleic Acid Conformation
Point Mutation
RNA, Ribosomal
RNA, Transfer

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