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Discordant and chameleon sequences: Their distribution and implications for amyloidogenicity

11 Jan 2011

Abstract excerpt

Identification of ambiguous encoding in protein secondary structure is paramount to develop an understanding of key protein segments underlying amyloid diseases. We investigate two types of structurally ambivalent peptides, which were hypothesized in the literature as indicators of amyloidogenic proteins: discordant α-helices and chameleon sequences. Chameleon sequences are peptides discovered experimentally in...

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PMID: 21432934
DOI: 10.1002/pro.590

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