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Article

Prediction of "hot spots" of aggregation in disease-linked polypeptides.

BMC structural biology - 30 Sept 2005

Sánchez de Groot Natalia, Pallarés Irantzu, Avilés Francesc X, Vendrell Josep, Ventura Salvador

Abstract excerpt

BACKGROUND: The polypeptides involved in amyloidogenesis may be globular proteins with a defined 3D-structure or natively unfolded proteins. The first class includes polypeptides such as beta2-microglobulin, lysozyme, transthyretin or the prion protein, whereas beta-amyloid peptide, amylin or alpha-synuclein all belong to the second class. Recent studies suggest that specific regions in the proteins act as "hot...

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Identifiers

PMID: 16197548
DOI: 10.1186/1472-6807-5-18
PMCID: PMC1262731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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