Article

Categorizing prediction modes within low-pLDDT regions of AlphaFold2 structures

2025-06-07

Abstract excerpt

AlphaFold2 protein structure predictions are widely available for structural biology uses. These predictions, especially for eukaryotic proteins, frequently contain extensive regions predicted below the pLDDT 70 level, the rule-of-thumb cutoff for high confidence. This work identifies major modes of behavior within low-pLDDT regions through a survey of human proteome predictions provided by the AlphaFold Protein S...

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Literature Corpus work: 42e04a10-9839-5f76-a90f-600c0e71b753
DOI: 10.1101/2025.06.06.658382

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