Platelet function and antiplatelet therapy in cardiovascular disease: implications of genetic polymorphisms.

doi:10.2174/157016111796197224

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Article

Platelet function and antiplatelet therapy in cardiovascular disease: implications of genetic polymorphisms.

Current vascular pharmacology - 1 Jul 2011

Shanker Jayashree, Gasparyan Armen Yuri, Kitas George D, Kakkar Vijay V

Abstract excerpt

Platelets play a crucial role in thrombosis, inflammation, immunity and atherogenesis. Antiplatelet agents are widely used in patients with acute coronary syndrome and other cardiovascular disorders. Aspirin and clopidogrel are the most commonly prescribed antiplatelet agents, with a relatively safe profile and efficiency in a variety of clinical conditions. Numerous prospective studies have revealed variability...

Topics

Aspirin
Blood Platelets
Cardiovascular Diseases
Clopidogrel
Genetic Variation
Genotype
Haplotypes
Humans
Platelet Aggregation Inhibitors
Platelet Function Tests
Polymorphism, Genetic
Ticlopidine

Source

Open in PubMed

Identifiers

PMID: 21314637
DOI: 10.2174/157016111796197224

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