Article
Association of platelet ADP receptor variant rs1371097 with inadequate platelet response to aspirin in Indian patients.
Personalized medicine - 1 Oct 2025
Sundaravadivel Pandarisamy, Christopher Rita, Chandra Sadanandavalli Retnaswami, Ramakrishnan Subasree
Abstract excerpt
AIM: On-aspirin platelet reactivity, wherein patients show sub-optimal or no response to antiplatelet therapy, occurs in 5-60% of subjects. The genetic etiology of such reactivity in patients with vascular diseases, especially ischemic stroke in the Indian population, is unknown. This study aimed to examine the genetic variations in the pathways of platelet aggregation and aspirin metabolism that could predict...
Topics
- Humans
- Aspirin
- Male
- Female
- Middle Aged
- India
- Platelet Aggregation
- Platelet Aggregation Inhibitors
- Prospective Studies
- Polymorphism, Single Nucleotide
- Aged