Article
Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine.
Cell metabolism - 1 May 2005
Teramoto Takayuki, Lambie Eric J, Iwasaki Kouichi
Abstract excerpt
The transient receptor potential (TRP) channels are implicated in various cellular processes, including sensory signal transduction and electrolyte homeostasis. We show here that the GTL-1 and GON-2 TRPM channels regulate electrolyte homeostasis in the C. elegans intestine. GON-2 is responsible for a large outwardly rectifying current of intestinal cells, and its activity is tightly regulated by intracellular...
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