Examining the Basis of Isoniazid Tolerance in Nonreplicating <i>Mycobacterium Tuberculosis</i> Using Transcriptional Profiling

Abstract excerpt

BACKGROUND: Understanding how growth state influences Mycobacterium tuberculosis responses to antibiotic exposure provides a window into drug action during patient chemotherapy. In this article, we describe the transcriptional programs mediated by isoniazid (INH) during the transition from log-phase to nonreplicating bacilli, from INH-sensitive to INH-tolerant bacilli respectively, using the Wayne model. RESULTS:...

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